dvnfit666
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Human chorionic gonadotropin
Human chorionic gonadotropin (hCG) is used to induce final oocyte maturation and to provide luteal phase support during in vitro fertilization treatment. hCG is usually given via IM route, but SC route has also been described. Stelling et al evaluated serum and follicular fluid levels of hCG after an IM or SC injection of 10,000 IU of hCG 36 hours after injection at the time of oocyte retrieval. SC administration achieves a significantly higher hCG level in serum (348.6±98 IU/L versus 259.0±115 IU/L, P=0.014) and follicular fluid (233.5±85 IU/L versus 143.4±134 IU/L, P=0.021) compared with IM group despite of a nonsignifi-cant difference in pregnancy rates between the two groups. SC hCG obtains the desired clinical effects with less patient inconvenience.97
Obese women had markedly lower Cmax, AUC, and average concentration (Cav) of hCG as compared with normal-weight women after SC injection (all P<0.05); however, the pharmacokinetic parameters were similar for normal-weight and obese women after IM injection.98 Thus, IM route may be more suitable for obese women who would receive hCG.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494621/